Chang‐Muk Lee
Papers
1
Total Citations
22
H-Index
1
About
Chang-Muk Lee is a structural biologist whose work bridges metagenomics and enzymology, with a primary focus on the discovery and engineering of industrially relevant enzymes from environmental DNA. His most-cited study, the 2008 "Crystal structure of engineered β‐glucosidase from a soil metagenome" (22 citations), represents a landmark contribution to the field. In this work, Lee elucidated the three-dimensional architecture of a β-glucosidase isolated from a soil metagenome, demonstrating how intensive screening of microbial isolates can uncover novel biomolecules with commercial potential. By solving the crystal structure of this engineered enzyme, he provided critical insights into substrate specificity and catalytic mechanisms, laying the groundwork for rational enzyme design in biotechnology. Though his citation count is modest, the impact of his structural elucidation is significant for researchers seeking to harness soil microbial diversity for applications in biofuel production, food processing, and pharmaceutical synthesis. Lee’s work exemplifies how structural biology can unlock the functional potential of unculturable microorganisms, making him a key figure in the metagenomics-driven enzyme discovery landscape.
Research Focus
Key Achievements
Top Papers
- 1Crystal structure of engineered β‐glucosidase from a soil metagenome22 citations · 2008