Cecilie Maria Madsen
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1
Total Citations
36
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1
About
Cecilie Maria Madsen is a pharmaceutical scientist whose research focuses on the biopharmaceutics of poorly soluble compounds, particularly their behavior in the gastrointestinal tract. Her work centers on understanding how the composition of intestinal media influences drug solubility—a critical factor for oral drug absorption and formulation development. In her most-cited study, "Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments" (2017, 36 citations), Madsen systematically applied design of experiments to reveal how variations in bile salts, lecithin, and pH in simulated intestinal fluids can dramatically alter solubility outcomes. This contribution provides a robust, data-driven framework for predicting drug performance in vivo, helping to bridge the gap between in vitro testing and clinical efficacy. Her research is particularly valuable for pharmaceutical scientists developing formulations for low-solubility drugs, offering practical guidance for selecting biorelevant media. Madsen’s work exemplifies the integration of experimental design and biopharmaceutical science, advancing our ability to optimize oral drug delivery.
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