Carlijn V. C. Bouten

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About

Dr. Carlijn V. C. Bouten is a pioneering figure in cardiovascular regenerative medicine and soft biohybrid robotics, whose work bridges fundamental mechanobiology with translational device design. Her research focuses on understanding how mechanical forces guide tissue formation and applying these principles to create living, functional heart replacements. Among her most notable contributions is the concept of a soft robotic total artificial hybrid heart—a groundbreaking approach that combines soft robotic actuation with a biologically compatible inner lining to overcome the biocompatibility and mechanical limitations of traditional total artificial hearts. This work, published in 2025, has already garnered significant attention and represents a paradigm shift in treating end-stage heart failure. Dr. Bouten’s broader impact is reflected in her highly cited body of work, which has shaped the fields of tissue-engineered heart valves, in vitro disease modeling, and mechanobiology. Her achievements include leading interdisciplinary teams that merge engineering, biology, and clinical needs, and her research continues to inspire new generations of scientists to rethink the boundaries of artificial organ design.