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Bohdana Fedyshyn is a prominent molecular biologist whose research centers on microbial genetics, functional genomics, and synthetic biology. Her most impactful contribution is the development of eSGA (E. coli synthetic genetic array analysis), a high-throughput method for systematically mapping genetic interactions in bacteria. This groundbreaking tool, detailed in her 2008 paper with 256 citations, enables researchers to rapidly construct double mutants and quantify their fitness effects, revealing functional relationships between genes. By adapting yeast synthetic genetic array techniques to E. coli, Fedyshyn provided a powerful platform for uncovering gene function, pathway organization, and the genetic basis of antibiotic resistance. Her work has significantly advanced our understanding of bacterial genetic networks and has been widely adopted in laboratories studying microbial systems biology. Fedyshyn’s eSGA method remains a cornerstone technology for probing the complex interplay of genes in prokaryotes, demonstrating her lasting impact on the field of bacterial genetics and synthetic biology.