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About

Oxana Pogoutse is a molecular biologist whose work has significantly advanced high-throughput genetic interaction mapping in bacteria. Her primary research focuses on functional genomics and systems biology, particularly in *Escherichia coli*. Her most notable contribution is the development of the eSGA (E. coli synthetic genetic array) method, a powerful technique for systematically constructing double mutants and analyzing genetic interactions on a genome-wide scale. This innovative approach, detailed in her highly cited 2008 paper (256 citations), enables researchers to rapidly identify functional relationships between genes, shedding light on pathway redundancy, cellular robustness, and the architecture of bacterial genetic networks. By adapting the synthetic genetic array concept from yeast to bacteria, Pogoutse provided a foundational tool for probing the complex wiring of prokaryotic cells. Her work has been instrumental in moving bacterial genetics from single-gene studies to comprehensive, systems-level analyses, offering critical insights into how *E. coli*—a model organism and industrial workhorse—organizes its essential functions.