Bjoern C. Froehlich

Papers

Total Citations

H-Index

About

Bjoern C. Froehlich is a leading figure in the advancement of mass spectrometry-based proteomics, with a particular focus on developing high-sensitivity, quantitative methods for analyzing proteins and peptides from extremely limited biological samples. His most cited work, "Immuno-MALDI-MS for Accurate Quantitation of Targeted Peptides from Volume-Restricted Samples" (2022, 4 citations), exemplifies his core contribution: integrating immunoaffinity enrichment with MALDI-TOF mass spectrometry to achieve precise, reproducible quantitation of target peptides from sub-microliter volumes. This approach overcomes a critical bottleneck in clinical proteomics, enabling the reliable measurement of low-abundance biomarkers from precious samples like cerebrospinal fluid, tears, or tissue biopsies. Froehlich’s research bridges the gap between discovery proteomics and clinical translation, providing a robust platform for targeted assays that require minimal sample input without sacrificing accuracy. His work is foundational for researchers seeking to move from broad protein identification to precise, hypothesis-driven quantitation in volume-constrained settings. By pushing the boundaries of what is analytically possible with small samples, Froehlich is empowering new avenues in biomarker validation, personalized medicine, and fundamental biological discovery.