Bartosz A. Grzybowski

About

Bartosz A. Grzybowski is a pioneering researcher at the intersection of chemistry, artificial intelligence, and robotics, whose work is reshaping how scientists discover and optimize chemical reactions and materials. His research focuses on autonomous and closed-loop chemical discovery, reaction optimization, and the application of machine learning to navigate vast chemical spaces that would be intractable by traditional means. Among his most influential contributions is the development of closed-loop, AI-driven platforms for identifying general reaction conditions—such as those for heteroaryl Suzuki-Miyaura coupling—earning over 200 citations and demonstrating that automation can uncover broadly applicable synthetic strategies beyond the narrow scope of human-guided experimentation. His delocalized, cloud-based discovery framework for organic laser emitters (130+ citations) showcases how geographically distributed expertise can be seamlessly integrated into autonomous research workflows. Grzybowski has also explored unexpected frontiers, from electronics-free optomechanical robots inspired by plant motion to geometrically novel "trajectoid" objects engineered to follow prescribed rolling paths. His broader impact extends to pressing societal challenges, including applying chemical AI to combat illicit drug synthesis. Across his career, Grzybowski has consistently demonstrated that the fusion of robotics, computation, and chemistry can fundamentally accelerate scientific discovery.

Research Focus

Key Achievements

Top Papers

1. 1
   Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling

   209 citations · 2022
2. 2
   Delocalized, asynchronous, closed-loop discovery of organic laser emitters

   130 citations · 2024
3. 3
   A computer algorithm to discover iterative sequences of organic reactions

   29 citations · 2022
4. 4
   Artificial Heliotropism and Nyctinasty Based on Optomechanical Feedback and No Electronics

   20 citations · 2017
5. 5
   Delocalized, Asynchronous, Closed-Loop Discovery of Organic Laser Emitters

   16 citations · 2023
6. 6
   Solid-body trajectoids shaped to roll along desired pathways

   11 citations · 2023
7. 7
   Robot-assisted mapping of chemical reaction hyperspaces and networks

   9 citations · 2025
8. 8
   Catalyst: Curtailing the scalable supply of fentanyl by using chemical AI

   9 citations · 2024

Key Collaborators

Contact & Links