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Assia Ouanaya is pioneering the integration of imaging and molecular profiling to decode cellular identity at single-cell resolution. Her landmark work, “Single-cell phenomics through integrated imaging and molecular profiling” (2025, 3 citations), introduces a transformative framework that merges microscopy, transcriptomics, and flow cytometry into a unified analytical platform. By enabling multimodal profiling of the same cell, Ouanaya’s approach allows researchers to correlate morphological features with gene expression and protein markers, offering a holistic view of cellular states that was previously unattainable. This breakthrough addresses a critical bottleneck in single-cell biology—the inability to link visual phenotypes with molecular data—and opens new avenues for understanding heterogeneity in development, disease, and therapeutic response. Though early in its citation trajectory, the paper’s conceptual rigor and methodological innovation signal its potential to become a foundational reference in phenomics. Ouanaya’s work exemplifies how cross-disciplinary integration can push the boundaries of what single-cell technologies can reveal, positioning her as a rising leader in the quest to map the full complexity of cellular life.