Papers
5
Total Citations
56
H-Index
4
About
Ali Hosni is a leading surgical oncologist whose research focuses on refining treatment paradigms for head and neck cancers, particularly through the integration of transoral robotic surgery (TORS) with radiotherapy de-intensification. His major contributions center on improving outcomes for patients with carcinoma of unknown primary (CUP) and oropharyngeal squamous cell carcinoma (OPSCC). Hosni’s work demonstrates that TORS-assisted lingual tonsillectomy can significantly enhance the identification of hidden base-of-tongue tumors, enabling more targeted, less toxic radiotherapy. His landmark study on radiation volume de-intensification in p16-positive CUP (the FIND trial, 2022) showed that reducing radiotherapy fields based on TORS findings can maintain oncologic control while minimizing treatment-related morbidity. With over 30 citations for his foundational 2016 paper on CUP vs. T1 base-of-tongue carcinoma, Hosni has also pioneered the use of pre-operative SPECT-CT lymphatic mapping to guide unilateral neck management, reducing contralateral nodal failure rates in lateralized OPSCC. His research has directly influenced clinical guidelines, shifting practice toward more personalized, de-escalated treatment strategies that preserve quality of life without compromising survival.
Research Focus
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