Adriaan Cleton
Papers
1
Total Citations
127
H-Index
1
About
Adriaan Cleton is a distinguished researcher whose work sits at the intersection of bioanalytical chemistry and clinical pharmacology, with a primary focus on the development and application of mass spectrometry-based methods for quantifying therapeutic targets and biomarkers. His major contributions include pioneering a sequential protein and peptide immunoaffinity capture technique coupled with mass spectrometry, enabling the precise quantification of total human β-nerve growth factor (NGF). This work, which has garnered over 127 citations, was critical for supporting clinical trials of tanezumab, a monoclonal antibody for chronic pain, by providing a robust method to measure NGF levels in complex biological matrices. Cleton’s research has significantly advanced the field of targeted proteomics, offering powerful tools for drug development and biomarker validation. His notable achievements include bridging the gap between immunoassay and mass spectrometry, demonstrating how hybrid approaches can overcome traditional limitations in sensitivity and specificity. For students and researchers, Cleton’s work exemplifies how rigorous analytical chemistry can directly enable translational medicine and the clinical success of novel therapeutics.
Research Focus
Key Achievements
Top Papers
- 1