A. George
Papers
1
Total Citations
167
H-Index
1
About
A. George is a leading figure in biophysical chemistry, whose work has fundamentally advanced the understanding of protein crystallization. His most influential contribution, the seminal 1997 paper "Second virial coefficient as predictor in protein crystal growth," has garnered 167 citations and established a critical, quantitative framework for the field. George demonstrated that the osmotic second virial coefficient (B22) serves as a reliable thermodynamic predictor of solution conditions favorable for protein crystal nucleation and growth. By defining the "crystallization slot"—a narrow range of slightly negative B22 values—he provided researchers with a powerful, rational tool to replace empirical trial-and-error methods. This insight has had a profound impact on structural biology, enabling more efficient production of high-quality protein crystals for X-ray diffraction. George's work bridges fundamental solution theory with practical applications in macromolecular crystallography, making him a key figure for any student or researcher seeking to understand or optimize protein crystal growth.
Research Focus
Key Achievements
Top Papers
- 1[6] Second virial coefficient as predictor in protein crystal growth167 citations · 1997