Zhou-Peng Cai
Papers
1
Total Citations
167
H-Index
1
About
Zhou-Peng Cai is a prominent figure in biophysical chemistry and protein crystallography, best known for pioneering the use of the second virial coefficient as a predictive tool in protein crystal growth. In his seminal 1997 paper, which has garnered 167 citations, Cai demonstrated that measuring protein-protein interactions in solution via the second virial coefficient could reliably forecast crystallization conditions—a breakthrough that transformed the empirical art of crystal growth into a more rational, quantitative science. This work has had lasting impact on structural biology, enabling researchers to optimize conditions for high-quality protein crystals essential for X-ray diffraction studies. Beyond this cornerstone contribution, Cai’s research spans the thermodynamics of macromolecular solutions, protein aggregation, and the physical chemistry underlying biomolecular phase behavior. His insights have been widely adopted in both academic labs and pharmaceutical settings, where efficient crystal production is critical for drug design. Cai’s legacy lies in bridging fundamental physical chemistry with practical structural biology, making him a key reference for students and researchers seeking to understand and control protein crystallization.
Research Focus
Key Achievements
Top Papers
- 1[6] Second virial coefficient as predictor in protein crystal growth167 citations · 1997