Todd W. Mitchell

Papers

Total Citations

146

H-Index

About

Todd W. Mitchell is a leading figure in lipidomics, with a research focus on developing innovative analytical methods to probe the lipid landscapes of biological systems, particularly the human brain. His major contributions lie in advancing high-throughput and single-cell lipid profiling technologies. In his highly cited 2013 work (86 citations), Mitchell introduced an improved lipid extraction protocol using methyl-tert-butyl ether (MTBE), offering a faster, more efficient alternative to the traditional Folch method for analyzing complex human brain samples. This breakthrough has enabled large-scale lipidomic studies with unprecedented throughput. Mitchell further pushed the boundaries of sensitivity and spatial resolution in his 2012 study (60 citations), where he demonstrated the first direct lipid profiling of single cells from inkjet-printed microarrays. By combining robotic liquid microextraction with chip-based nanoelectrospray ionization, he created a powerful platform for interrogating individual cells, opening new avenues for understanding cellular heterogeneity in lipid metabolism. His work has been instrumental in bridging the gap between bulk tissue analysis and single-cell resolution, providing essential tools for neuroscience and biomedical research.