Theresa Towle

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About

Theresa Towle is a researcher whose work has centered on advancing early-stage drug development through innovative assay technologies. Her primary research areas include ADME/Tox (Absorption, Distribution, Metabolism, Excretion, and Toxicity) screening and microfluidic platform development. Towle’s most notable contribution is her 2003 paper, “ADMET Assays on Tecan’s LabCD-ADMET System,” which pioneered the integration of critical pharmacokinetic assays—Cytochrome P450 Inhibition, Serum Protein Binding, and P-glycoprotein Interaction—onto a compact, centrifugal microfluidic platform. This work demonstrated how miniaturization could streamline the evaluation of drug candidates’ safety and efficacy profiles, addressing a key bottleneck in pharmaceutical R&D. While her highly specialized paper has garnered 4 citations, its significance lies in its early proof-of-concept for lab-on-a-disc technologies in ADMET screening, a field that has since grown substantially. Towle’s research has contributed to the broader push for more efficient, high-throughput preclinical testing, offering a foundation for subsequent innovations in microfluidics and automated drug discovery. Her work remains a reference point for researchers exploring integrated, miniaturized systems for pharmacokinetic analysis.