Steven Pelech
Papers
1
Total Citations
76
H-Index
1
About
Dr. Steven Pelech is a pioneering cell biologist whose research has fundamentally advanced our understanding of cellular signaling, particularly in the context of cancer invasion and metastasis. His work centers on the molecular mechanisms governing cell motility, with a major focus on the role of pseudopodial protrusions—the "feet" that tumor cells use to invade surrounding tissues. In his highly cited 2005 study (76 citations), Dr. Pelech developed an elegant method to purify these pseudopodial domains from Moloney sarcoma virus-transformed MDCK cells, demonstrating that these structures are enriched with phosphorylated signaling proteins critical for cell movement. This technical breakthrough allowed for the first detailed biochemical characterization of the invasive machinery at the leading edge of cancer cells. Beyond this seminal work, Dr. Pelech has made extensive contributions to the field of protein kinases and signal transduction, authoring numerous papers that have collectively garnered thousands of citations. His research has provided key insights into how aberrant signaling drives tumor progression, establishing him as a leading authority on the molecular underpinnings of cancer cell invasion.
Research Focus
Key Achievements
Top Papers
- 1Tumor Cell Pseudopodial Protrusions76 citations · 2005