S. Danielle MacNeil
Papers
9
Total Citations
870
H-Index
7
About
Dr. S. Danielle MacNeil is a leading head and neck surgical oncologist whose research has fundamentally shaped the debate on the optimal treatment for oropharyngeal squamous cell carcinoma (OPSCC), particularly in the era of HPV-related disease. Her landmark work centers on the comparative effectiveness of transoral robotic surgery (TORS) versus primary radiotherapy. As the principal investigator of the ORATOR trial, she led the first randomized controlled trial to directly compare these modalities, with the initial 2019 results (458 citations) and the final 2024 outcomes providing crucial, high-level evidence on survival and functional outcomes. Her systematic reviews and sub-studies, including analyses of swallowing function, have further clarified the trade-offs between these approaches. By rigorously challenging assumptions and providing randomized data, Dr. MacNeil’s research has empowered clinicians and patients to make more informed decisions, establishing her as a pivotal figure in the evidence-based management of early-stage oropharyngeal cancer.
Research Focus
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Top Papers
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