Ran Brosh
Papers
2
Total Citations
62
H-Index
2
About
Ran Brosh is a pioneering researcher at the forefront of synthetic genomics and mammalian genome engineering. Their work centers on the design, assembly, and delivery of large-scale DNA constructs, with a particular focus on overcoming the technical barriers to studying and manipulating mammalian genomes. Brosh’s major contribution is the landmark achievement of *de novo* assembly and functional delivery of a 101 kb human gene into mouse cells—a feat that demonstrated the feasibility of bottom-up synthetic biology for complex eukaryotic systems. This work, published in 2021 and garnering 55 citations, has opened new avenues for gene therapy, functional genomics, and the construction of synthetic mammalian chromosomes. Brosh’s research addresses two critical challenges: scaling DNA synthesis to mammalian-sized genes and ensuring their proper expression in living cells. By pushing the boundaries of what can be built and expressed from scratch, Brosh is laying the groundwork for transformative applications in medicine and biotechnology, making their contributions essential reading for students and researchers interested in the future of genome writing and synthetic biology.
Research Focus
Key Achievements
Top Papers
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