Matthew T. Maurano
Papers
2
Total Citations
62
H-Index
2
About
Matthew T. Maurano is a pioneering researcher at the intersection of synthetic biology and functional genomics, with a core focus on engineering large-scale DNA constructs to study mammalian gene regulation. His most influential work centers on the *de novo* assembly, delivery, and expression of a 101 kb functional human gene in mouse cells—a landmark achievement that demonstrates the feasibility of bottom-up genome engineering in complex mammalian systems. This research, which has garnered over 55 citations, directly tackles two major challenges: the synthesis of megabase-scale DNA and its functional delivery into living cells. By successfully expressing a full-length human gene in a mouse model, Maurano has opened new avenues for understanding gene function, disease mechanisms, and therapeutic development. His contributions are particularly notable for pushing the boundaries of synthetic genomics beyond microbial and viral genomes, offering transformative potential for studying larger, more complex mammalian genomes. This work not only highlights his technical ingenuity but also positions him as a key figure in advancing the tools needed to decode the human genome’s regulatory logic.
Research Focus
Key Achievements
Top Papers
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