Rachel C. Doran
Papers
3
Total Citations
26
H-Index
2
About
Rachel C. Doran is a bioprocess engineer whose work sits at the critical intersection of synthetic biology and vaccine manufacturing, with a primary focus on HIV vaccine development. Her research centers on overcoming the formidable challenge of producing stable, high-yield envelope glycoproteins (Envs) in Chinese Hamster Ovary (CHO) cell lines—a bottleneck that has historically limited the efficacy and scalability of HIV vaccines. Doran’s most significant contribution is the development of a robotic selection platform that dramatically accelerates the creation of stable CHO cell lines, a breakthrough detailed in her highly cited 2018 paper (21 citations). This innovation addresses the 10-100 fold yield deficit of Envs compared to other pharmaceutical glycoproteins. She further advanced the field by engineering a stable MGAT1− CHO cell line, which produces clade C gp120 with enhanced binding to broadly neutralizing antibodies, a critical step toward a globally effective vaccine. By integrating automation with cell line engineering, Doran’s work not only pushes the frontier of HIV vaccinology but also provides a scalable template for producing complex biologics, positioning her as a key figure in the next generation of biomanufacturing.
Research Focus
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Top Papers
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