Ninel Z. Gregori
Papers
1
Total Citations
70
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1
About
Ninel Z. Gregori is a pioneering ophthalmologist and surgeon whose work centers on inherited retinal degenerations and the development of gene therapy delivery techniques. Her major contributions lie in refining the surgical approach for subretinal gene augmentation therapy, a critical step in treating conditions like choroideremia, RPE65 mutation-associated retinal dystrophy, and X-linked retinitis pigmentosa. Her landmark 2019 paper, "Surgical Technique for Subretinal Gene Therapy in Humans with Inherited Retinal Degeneration," has garnered 70 citations, reflecting its foundational role in the field. Notably, Gregori was among only two surgeons worldwide who performed RPE65 gene therapy in the pivotal Phase 3 clinical trial that led to the first FDA-approved gene therapy for an inherited retinal disease. Her work has directly shaped the safety and reproducibility of subretinal injections, enabling broader clinical adoption. By bridging surgical precision with molecular medicine, Gregori has helped transform gene therapy from a theoretical promise into a life-changing reality for patients facing blindness.
Research Focus
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Top Papers
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