Ned Powell
Papers
1
Total Citations
18
H-Index
1
About
Dr. Ned Powell is a leading clinical researcher in head and neck oncology, with a primary focus on human papillomavirus (HPV)-positive oropharyngeal cancer. His major contributions center on de-escalation strategies to reduce treatment toxicity without compromising survival. He is best known for spearheading the PATHOS trial, a landmark phase II/III study investigating risk-stratified, reduced-intensity adjuvant therapy following transoral surgery for HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). This work addresses the critical challenge that existing treatments, while highly effective, often cause severe long-term toxicities. The PATHOS trial, cited 18 times, represents a paradigm shift toward personalized, function-preserving care. Dr. Powell’s research has been instrumental in demonstrating that HPV-positive OPSCC patients may be safely managed with less aggressive regimens, improving quality of life. His ongoing impact is reflected in his leadership of practice-changing clinical trials and his dedication to translating molecular insights into patient-centered treatment protocols. For students and researchers, Dr. Powell exemplifies how rigorous clinical investigation can directly reshape standards of care in oncology.
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Top Papers
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