Massimo Pasqualetti

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About

Massimo Pasqualetti is a leading neuroscientist whose research lies at the intersection of neuroplasticity, serotonin signaling, and rehabilitation robotics. His work has fundamentally advanced our understanding of how to enhance brain recovery after stroke by pharmacologically priming plasticity mechanisms. In his landmark 2021 study, "Combining robotics with enhanced serotonin-driven cortical plasticity improves post-stroke motor recovery," Pasqualetti demonstrated that pairing robotic rehabilitation with serotonin-driven plasticity augmentation significantly improves motor outcomes—a clinically relevant strategy that bridges basic neurobiology and cutting-edge technology. This highly cited work (6 citations) has opened new avenues for designing more effective post-stroke therapies by addressing a critical gap: the insufficient enhancement of plasticity in conventional robotic rehabilitation. Pasqualetti’s contributions are particularly notable for their translational potential, offering a blueprint for integrating pharmacological and robotic interventions to maximize functional recovery. His research continues to shape the fields of neurorehabilitation and neuromodulation, inspiring both clinicians and engineers to rethink how we restore movement after neurological injury.