Lyle Isaacs
Papers
1
Total Citations
10
H-Index
1
About
Lyle Isaacs is a leading figure in supramolecular chemistry, best known for his pioneering work on cucurbit[n]uril (CB[n]) host molecules. His research focuses on the design, synthesis, and application of these pumpkin-shaped macrocycles for molecular recognition, self-assembly, and drug delivery. Isaacs made a landmark contribution by developing methods to create functionalized CB[n] derivatives, dramatically expanding their utility in aqueous environments. His work has been cited over 10,000 times, reflecting its profound impact on fields ranging from chemical biology to materials science. Notably, he has advanced predictive modeling through community blind challenges, aiming to improve the accuracy of free energy calculations for biomolecular interactions—a critical step toward rational drug design. Isaacs’ achievements include the development of CB[7] as a high-affinity host for drug solubilization and controlled release, and his studies on the thermodynamics of host-guest complexes have set benchmarks in the field. His research continues to inspire new generations of supramolecular chemists.
Research Focus
Key Achievements
Top Papers
- 1