Luca Annecchino

Imperial College London, London Centre for Nanotechnology

Papers

Total Citations

133

H-Index

About

Luca Annecchino is a neuroscientist and engineer whose work sits at the intersection of automation, optics, and cellular electrophysiology. His primary research focus is the development of robotic systems for in vivo whole-cell patch-clamp recording, a technique that allows precise measurement of neuronal activity in living animals. Annecchino’s major contribution is the creation of a robotic platform that integrates two-photon microscopy with automated patch-clamp electrophysiology, enabling targeted, high-throughput recording from genetically or morphologically defined neurons. His landmark 2017 paper, “Robotic Automation of In Vivo Two-Photon Targeted Whole-Cell Patch-Clamp Electrophysiology,” has garnered 70 citations, reflecting its significance in advancing automated cellular physiology. In his 2018 review, “Progress in automating patch clamp cellular physiology” (61 citations), he synthesized the evolution of these technologies, highlighting their potential to transform neuroscience research. Annecchino’s work bridges a critical gap between manual expertise and scalable automation, offering a powerful tool for dissecting cortical circuit dynamics. His achievements stand out for their technical ingenuity and practical impact, making him a key figure in the push toward fully automated, high-fidelity neuronal recording.