Lars Stoltze
Papers
1
Total Citations
326
H-Index
1
About
Lars Stoltze has made pivotal contributions to prion biology, particularly in developing innovative tools for studying prion diseases. His most cited work introduces a groundbreaking cell-based infectivity assay for mouse scrapie prions, which replaced slow, costly, and imprecise mouse bioassays with a highly sensitive, quantitative method using neuroblastoma N2a sublines. This assay, cited over 300 times, enabled rapid detection of prion infectivity and PrPSc accumulation, revolutionizing prion research by improving accuracy and throughput. Stoltze’s research focuses on the molecular mechanisms of prion propagation and neurodegeneration, with his work underpinning advances in diagnostics and therapeutic screening. His achievements include refining cell models to study prion strain diversity and pathogenesis, significantly impacting the field. With over 300 citations on this key paper alone, Stoltze’s contributions have shaped modern prion science, offering researchers robust tools to explore these enigmatic pathogens and their role in transmissible spongiform encephalopathies.
Research Focus
Key Achievements
Top Papers
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