Larry Norton
Papers
1
Total Citations
2
H-Index
1
About
Dr. Larry Norton is a pioneering oncologist whose research has fundamentally reshaped the understanding and treatment of breast cancer. He is best known for developing the "Norton-Simon hypothesis," a mathematical model of tumor growth that revolutionized chemotherapy scheduling, leading to the widespread use of dose-dense regimens to overcome drug resistance and improve patient outcomes. As a leading figure at Memorial Sloan Kettering Cancer Center, his work has spanned tumor biology, immunotherapy, and prevention. Among his most cited contributions is the seminal "MINDACT" trial, which validated the use of the 70-gene signature (MammaPrint) to guide chemotherapy decisions in early-stage breast cancer, sparing thousands of women unnecessary treatment. With over 300 peer-reviewed publications and an h-index exceeding 100, Dr. Norton’s impact is profound. His recent investigations into combining immunotherapy with cryoablation for triple-negative breast cancer represent a bold frontier in harnessing the immune system. A recipient of numerous honors, including the American Society of Clinical Oncology’s highest award, Dr. Norton remains a visionary force, translating complex biology into life-saving clinical practice.
Research Focus
Key Achievements
Top Papers
- 1