Kezia Addo
Papers
1
Total Citations
23
H-Index
1
About
Dr. Kezia Addo is a leading researcher in membrane biology and innate immunity, whose work has fundamentally reshaped our understanding of how lipid rafts orchestrate immune signaling. Her key contributions lie at the intersection of proteomics, cholesterol metabolism, and Toll-like receptor (TLR) function. In her landmark 2015 study, "Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling" (23 citations), Dr. Addo pioneered a novel approach to dissect raft biology. By analyzing macrophages lacking the cholesterol transporter ABCA1, she identified Stomatin-Like Protein-2 (SLP-2) as a critical, cholesterol-independent regulator of raft composition. This discovery challenged the prevailing dogma that raft organization is solely cholesterol-driven, revealing instead that SLP-2 directly controls the assembly of signaling platforms for TLRs. Her work has profound implications for understanding inflammatory diseases and developing targeted therapies. Dr. Addo’s innovative use of proteomics to map raft proteomes continues to inspire new directions in immunology and lipid biology, establishing her as a rising authority on the molecular architecture of immune cell membranes.
Research Focus
Key Achievements
Top Papers
- 1