Xuewei Zhu
Papers
1
Total Citations
23
H-Index
1
About
Xuewei Zhu is a leading investigator in macrophage biology and lipid metabolism, with a particular focus on the molecular mechanisms that govern innate immune signaling. Her work has fundamentally advanced our understanding of how cholesterol homeostasis and membrane microdomain organization regulate Toll-like receptor (TLR) function. In her highly cited 2015 study, Zhu employed a proteomic analysis of ABCA1-null macrophages to identify Stomatin-like protein-2 (SLP-2) as a critical regulator of lipid raft composition and TLR signaling. This work, which has garnered 23 citations, challenged the prevailing view that raft localization is solely controlled by cholesterol levels, revealing instead that SLP-2 acts as a key scaffold in organizing signaling complexes within these membrane domains. By demonstrating that ABCA1 deficiency alters the raft proteome and downstream inflammatory responses, Zhu provided a mechanistic link between cholesterol efflux pathways and innate immunity. Her contributions have significant implications for understanding the pathogenesis of atherosclerosis and other inflammatory diseases, where dysregulated lipid metabolism and immune activation converge.
Research Focus
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Top Papers
- 1