Kerryn Matthews

Papers

Total Citations

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About

Kerryn Matthews has pioneered transformative approaches in single-cell analysis, with her most-cited work focusing on "Lossless immunocytochemistry using photo-polymerized hydrogel thin-films" (2020, 4 citations). Her primary research centers on developing innovative techniques to overcome fundamental limitations in immunocytochemistry (ICC) and immunofluorescence microscopy—critical tools for cell phenotyping in both research and clinical diagnostics. Matthews’ major contribution addresses a persistent challenge: standard ICC methods fail with small cell populations (under 10,000 cells), leading to sample loss and unreliable results. She introduced a novel hydrogel thin-film technology that physically entraps cells during staining, enabling "lossless" processing of rare or precious samples. This breakthrough allows researchers to obtain high-quality phenotypic data from minimal starting material, dramatically expanding the utility of ICC for applications like circulating tumor cell analysis, stem cell characterization, and fine-needle biopsies. While her citation count reflects the early stage of this work, its potential impact is significant—offering a practical solution to a long-standing technical bottleneck in cellular analysis. Matthews’ research exemplifies how materials science can directly address pressing needs in biological and clinical research.