Kebing Yu

Papers

Total Citations

114

H-Index

About

Kebing Yu is a pioneering researcher whose work bridges chemical biology, cancer therapeutics, and proteomics. His most cited study, “Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis” (2015, 114 citations), made a landmark contribution by identifying brusatol as a potent inhibitor of global protein synthesis, rather than a direct KEAP1/Nrf2 pathway modulator as previously assumed. This discovery reshaped understanding of how natural compounds can target the Nrf2 pathway—a critical sensor of oxidative stress often constitutively activated in non-small cell lung cancer and other tumors. By employing advanced mass spectrometry profiling, Yu provided a mechanistic framework for developing Nrf2 inhibitors as cancer therapeutics. His work has garnered significant attention, with over 100 citations, underscoring its impact on both fundamental redox biology and translational oncology. Yu’s research exemplifies how precise chemical tools can unravel complex biological mechanisms, offering new avenues for treating cancers driven by Nrf2 hyperactivation. His contributions continue to inspire students and researchers exploring the intersection of proteomics and drug discovery.