Karen Roberts
Papers
3
Total Citations
84
H-Index
3
About
Karen Roberts is a leading expert in the automation and optimization of high-throughput screening, with a primary focus on the precision of compound dosing in cell-based assays. Her most impactful contribution is the validation and implementation of Acoustic Droplet Ejection (ADE) technology, a method that revolutionized compound handling by enabling direct, contactless dosing into assay plates. Her seminal 2009 paper, "Achieving Accurate Compound Concentration in Cell-Based Screening," which has garnered 58 citations, established ADE as a gold standard for accuracy in drug discovery. Roberts’ subsequent work, including her 2015 paper on the challenges of direct acoustic dosing (22 citations), documents the global adoption of this technology at AstraZeneca, where it became the preferred method for both biochemical and cell-based assays. She also advanced laboratory efficiency by designing integrated robotic work cells that multiplex cellular assays, dramatically reducing footprint and reagent use. Through her pioneering efforts, Roberts has fundamentally shaped modern screening workflows, enabling more reliable data and accelerating the drug development pipeline.
Research Focus
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