Joseph W. Keating
Papers
1
Total Citations
15
H-Index
1
About
Joseph W. Keating is a leading innovator at the intersection of structural biology and analytical chemistry, whose work has fundamentally advanced the field of native mass spectrometry. His primary research focuses on developing high-throughput methodologies to probe the higher-order structures of biomolecules, with a particular emphasis on collision-induced unfolding (CIU) experiments. Keating’s most significant contribution is the creation of an automated, high-throughput platform for native ion mobility mass spectrometry (nIM-MS), a breakthrough that enables the rapid evaluation of protein stability and conformational dynamics. This work, detailed in his highly cited 2023 paper, has transformed CIU from a labor-intensive technique into a scalable tool for drug discovery and biotherapeutic characterization. By combining nIM-MS with collisional activation, his methodology provides unprecedented insight into biomolecular structural integrity, allowing researchers to assess how ligands or environmental changes affect protein folding. Though his citation count is still growing, Keating’s impact is already evident in the pharmaceutical industry, where his automated approach is accelerating the analysis of monoclonal antibodies and other complex therapeutics. His achievements mark him as a rising star in structural mass spectrometry, bridging the gap between fundamental biophysics and practical, industrial application.
Research Focus
Key Achievements
Top Papers
- 1