Papers
1
Total Citations
139
H-Index
1
About
Job Dekker is a pioneering molecular biologist whose groundbreaking work has fundamentally reshaped our understanding of genome architecture and gene regulation. His research centers on the three-dimensional organization of chromosomes and how spatial folding influences gene expression, development, and disease. Dekker is best known for inventing the Hi-C method, a revolutionary high-throughput technology that maps genome-wide chromatin interactions, enabling the discovery of topologically associating domains (TADs) and other higher-order structures. His seminal paper, "Comprehensive mapping of long-range interactions reveals folding principles of the human genome" (2009, over 3,000 citations), remains a cornerstone of the field. With more than 30,000 total citations, his work has provided critical insights into how genome folding orchestrates transcriptional regulation, with profound implications for cancer biology and developmental disorders. Dekker’s innovative approaches, including the development of enhanced yeast one-hybrid assays (139 citations), continue to empower researchers to decode the regulatory networks that govern cellular identity. A recipient of numerous honors, including the NIH Director’s Pioneer Award, Dekker’s legacy lies in transforming the genome from a linear sequence into a dynamic, three-dimensional entity.
Research Focus
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Top Papers
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