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Total Citations
139
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About
Amanda Kent is a molecular biologist whose work has fundamentally advanced our understanding of gene regulation through innovative high-throughput technologies. Her primary research focuses on developing and applying yeast one-hybrid (Y1H) assays to systematically map transcriptional regulatory networks. Kent’s landmark 2011 paper, "Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping," has garnered 139 citations and stands as a cornerstone in the field. In this work, she engineered a more robust and scalable Y1H system, enabling researchers to efficiently identify transcription factors that bind to specific DNA regulatory elements—a critical step in deciphering how genes are controlled in development and disease. By streamlining the process for genome-wide analysis, Kent’s contributions have empowered labs worldwide to uncover the wiring diagrams of cellular identity and response. Her methodological innovations have been widely adopted, making her a key figure in regulatory genomics. For students and researchers, Kent’s work exemplifies how clever assay design can unlock complex biological questions, offering a powerful toolkit for exploring the logic of gene expression.
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