Jerry Zweigenbaum
Papers
1
Total Citations
95
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1
About
Jerry Zweigenbaum is a pioneering figure in analytical chemistry, best known for his foundational work in coupling capillary electrophoresis with mass spectrometry. His landmark 1991 paper, "Capillary electrophoresis-atmospheric pressure ionization mass spectrometry for the characterization of peptides," demonstrated the first robust on-line integration of CE with API-MS, achieving 95 citations and establishing a critical methodology for peptide and protein analysis. This contribution enabled high-resolution separation of complex biological mixtures—such as synthetic peptides and tryptic digests of human hemoglobin—directly coupled to sensitive mass detection, a technique that has since become indispensable in proteomics and biopharmaceutical characterization. Zweigenbaum’s innovations advanced the field of hyphenated separation techniques, bridging the gap between electrophoretic resolution and mass spectrometric identification. His work has had lasting impact, influencing subsequent developments in microfluidic analysis and high-throughput biomolecule characterization. Researchers and students alike recognize his contributions as a cornerstone in the evolution of modern analytical platforms for peptide and protein science.
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