Janette Berglez
Papers
1
Total Citations
13
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1
About
Janette Berglez is a biochemist whose work has centered on the enzymology of folate biosynthesis in yeast, with a particular focus on the bifunctional enzyme dihydropterin pyrophosphokinase-dihydropteroate synthase (DHPPK-DHPS) from *Saccharomyces cerevisiae*. Her most-cited study, published in 2005, details the purification, kinetic properties, and crystallization of this enzyme—a critical target for antimicrobial drug development due to its absence in humans. By establishing a robust purification protocol and characterizing the enzyme’s catalytic behavior, Berglez provided foundational insights into the structural and functional mechanisms of folate pathway enzymes. This work has garnered 13 citations, reflecting its utility in subsequent studies on enzyme inhibition and structural biology. Her contributions are particularly notable for advancing the understanding of how yeast models can inform broader research on antifolate resistance and drug design. Berglez’s meticulous biochemical approach has made her a respected figure in enzymology, offering a clear framework for studying complex biosynthetic pathways.
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Top Papers
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