Patricia A. Pilling
Papers
1
Total Citations
13
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1
About
Patricia A. Pilling is a biochemist whose research centers on the structural and functional characterization of enzymes critical to microbial metabolism, particularly those involved in folate biosynthesis. Her most-cited work, a 2005 study on the purification, properties, and crystallization of *Saccharomyces cerevisiae* dihydropterin pyrophosphokinase-dihydropteroate synthase, has garnered 13 citations, establishing a foundation for understanding this bifunctional enzyme’s role in yeast. This contribution is notable for advancing the structural biology of folate pathway enzymes, which are key targets for antimicrobial drug development. Pilling’s meticulous purification and crystallization methods have enabled subsequent studies on enzyme kinetics and inhibitor design, underscoring her impact in enzymology. Her work exemplifies how detailed biochemical characterization can illuminate fundamental cellular processes and inform therapeutic strategies.
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