Hadley Wyre

Papers

Total Citations

H-Index

About

Dr. Hadley Wyre is a leading urologic surgeon and researcher whose work centers on optimizing recovery and quality of life for patients undergoing radical cystectomy (RC) for bladder cancer. Her most impactful contributions focus on perioperative care and patient resilience. Dr. Wyre’s landmark study on alvimopan demonstrated that this peripherally acting μ-opioid receptor antagonist significantly accelerates gastrointestinal recovery and reduces hospital length of stay following RC, a procedure notorious for post-operative ileus. This work, cited 19 times, has helped establish alvimopan as a standard component of enhanced recovery after surgery (ERAS) protocols in major urologic oncology centers. More recently, Dr. Wyre has pioneered the study of psychological factors in surgical outcomes. Her 2025 investigation into patient resilience revealed that higher pre-operative resilience scores are strongly associated with improved health-related quality of life after RC, even amidst substantial morbidity. This novel finding shifts the paradigm from purely physiological recovery to a holistic model that includes mental fortitude. Dr. Wyre’s research bridges surgical innovation with patient-centered outcomes, making her a vital voice in modern urologic oncology.