Gwen P. Tatsuno
Papers
2
Total Citations
23
H-Index
2
About
Gwen P. Tatsuno is a bioprocess engineer whose work lies at the critical intersection of automation, cell line development, and vaccine manufacturing. Her primary research focuses on overcoming the notoriously low yields of complex viral antigens, particularly HIV envelope glycoproteins (Envs), in Chinese Hamster Ovary (CHO) cell lines—a bottleneck that has long hampered the production of effective HIV vaccines. Her landmark 2018 paper, “Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production” (21 citations), introduces a high-throughput, robotic screening platform that dramatically accelerates the isolation of high-producing stable clones. By automating the selection process, Tatsuno’s method bypasses the slow, labor-intensive manual cloning that typically results in 10-100 fold lower yields for Envs compared to standard therapeutic proteins. This innovation not only shortens development timelines but also improves the consistency and quality of the expressed glycoproteins, making large-scale HIV vaccine manufacturing more feasible. Her work represents a pivotal step in translating fundamental virology into scalable, real-world production, and continues to influence the design of automated workflows for other challenging biologics.
Research Focus
Key Achievements
Top Papers
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