Dominique Poncelet
Papers
1
Total Citations
6
H-Index
1
About
Dominique Poncelet is a pioneer in the development of high-throughput, low-input epigenomic technologies, with a primary focus on automating chromatin biology for single-cell and rare-cell applications. Their most notable contribution is the automation of ChIP-seq protocols, enabling the generation of robust epigenetic profiles from as few as 10,000 HeLa cells—a dramatic reduction in material requirements that opened the door to studying clinically scarce samples. This work, which has garnered 6 citations, addressed the historically tedious and time-consuming nature of chromatin immunoprecipitation by streamlining workflows and improving reproducibility. Poncelet’s research sits at the intersection of microfluidics, epigenetics, and laboratory automation, directly tackling the challenge of mapping protein-DNA interactions and histone modifications with minimal input material. By pushing the boundaries of what is possible with limited cell numbers, their achievements have laid critical groundwork for translating epigenetic assays into clinical diagnostics and personalized medicine, where sample scarcity is a constant hurdle.
Research Focus
Key Achievements
Top Papers
- 1