David M. Jacobowitz
Papers
1
Total Citations
11
H-Index
1
About
David M. Jacobowitz is a molecular biologist whose research centers on high-throughput protein expression and functional genomics, with a particular focus on developing innovative tools to streamline the production of soluble proteins for structural and biochemical studies. His major contribution is the creation of Pooled ORF Expression Technology (POET), a pioneering method that combines recombinational cloning with proteomic techniques—such as two-dimensional gel electrophoresis and mass spectrometry—to rapidly identify open reading frames (ORFs) that yield high levels of soluble, purified protein. This work, published in 2005, has garnered 11 citations and represents a foundational step in reducing bottlenecks in protein production, enabling more efficient exploration of gene function. Jacobowitz’s approach has practical implications for drug discovery and synthetic biology, making him a notable figure in the advancement of expression technologies. His achievements highlight a commitment to bridging molecular cloning and proteomics, offering researchers a powerful tool to accelerate the study of proteins from diverse organisms.
Research Focus
Key Achievements
Top Papers
- 1Pooled ORF Expression Technology (POET)11 citations · 2005