David G. Frazer
Papers
3
Total Citations
222
H-Index
3
About
David G. Frazer is a leading researcher in occupational respiratory toxicology, with a focus on the health impacts of welding fume exposure. His work centers on understanding how complex metal oxide aerosols from welding processes affect lung function, inflammation, and immune defense. Frazer’s major contributions include the design and construction of a novel robotic welding fume generator and inhalation exposure system for laboratory animals, which has become a foundational tool in the field. His most-cited paper, "Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species" (94 citations), reveals critical mechanisms of oxidative stress induced by different fume types. Another highly influential study (93 citations) details the development of his exposure system, enabling controlled, reproducible inhalation studies. Frazer’s research has demonstrated that short-term mild steel fume exposure may not cause acute lung inflammation but can impair bacterial defense responses, as shown in a 2008 study (35 citations). His work has profound implications for occupational safety, helping to clarify the risks faced by over 390,000 U.S. welders and informing protective standards. Frazer’s innovative methodologies and mechanistic insights continue to shape our understanding of welding-related respiratory disease.
Research Focus
Key Achievements
Top Papers
- 1
- 2
- 3