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Total Citations
61
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About
B. Hughey is a pioneer in the application of accelerator mass spectrometry (AMS) to biomedical research, with a career dedicated to advancing the direct analysis of radiocarbon (¹⁴C) in biological specimens. Their most-cited work, "An Interface for Direct Analysis of ¹⁴C in Nonvolatile Samples by Accelerator Mass Spectrometry" (2003, 61 citations), introduced a groundbreaking method for analyzing liquid samples like plasma and urine by depositing them into a CuO powder bed within a refractory support. This innovation dramatically simplified sample preparation, enabling the direct measurement of ¹⁴C in complex biological matrices without extensive chemical processing. By bridging the gap between AMS—traditionally used in geochronology—and biomedical tracer studies, Hughey’s contributions have enabled ultrasensitive pharmacokinetic and metabolic research. Their work has been instrumental in reducing sample size requirements and improving throughput, making AMS more accessible for clinical and preclinical studies. Hughey’s achievements reflect a unique ability to engineer practical solutions for cutting-edge analytical challenges, leaving a lasting impact on the fields of bioanalytical chemistry and radiocarbon tracing.
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