Shawn Harriman
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1
Total Citations
61
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1
About
Shawn Harriman is a key figure in the development of bioanalytical accelerator mass spectrometry (AMS), specializing in the direct measurement of radiocarbon (¹⁴C) in biological samples. His most cited work, a 2003 paper with 61 citations, introduced a groundbreaking interface for the direct analysis of ¹⁴C in nonvolatile biological specimens such as plasma and urine. By depositing liquid samples directly into a CuO powder bed within a refractory support, Harriman’s method eliminated the need for labor-intensive sample combustion or graphitization, dramatically simplifying and accelerating AMS analysis for biomedical applications. This innovation enabled more efficient tracing of labeled compounds in pharmacokinetics and toxicology, making AMS more accessible for clinical and environmental studies. Harriman’s contributions have had a lasting impact on the field, facilitating high-throughput, sensitive detection of ¹⁴C in complex matrices and advancing the use of AMS as a tool for understanding metabolic pathways and drug disposition. His work remains a foundational reference for researchers seeking to bridge analytical chemistry with biomedical science.
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