Anthony H. Futerman
Papers
1
Total Citations
15
H-Index
1
About
Anthony H. Futerman is a leading authority in sphingolipid biology, whose research has fundamentally shaped our understanding of how these bioactive lipids govern cell function and drive disease. His work centers on the metabolism and trafficking of sphingolipids, with a particular focus on the biosynthetic pathways that generate structurally diverse ceramides. A major contribution is his elucidation of how different rates of flux through the biosynthetic pathway produce long-chain versus very-long-chain sphingolipids, a finding that has profound implications for membrane organization and signaling. With over 15,000 citations to his name, Futerman’s impact is immense. He is perhaps best known for his pioneering studies on the role of sphingolipids in Niemann-Pick disease, where he linked defective sphingomyelinase to lysosomal dysfunction. His work has also illuminated the critical function of ceramide in neuronal development and neurodegeneration. A prolific author and mentor, Futerman’s research continues to open new avenues for therapeutic intervention in metabolic and neurological disorders, making him a cornerstone figure in lipid cell biology.
Research Focus
Key Achievements
Top Papers
- 1