Andrew C. Overholt
Papers
1
Total Citations
56
H-Index
1
About
Andrew C. Overholt is a leading clinical researcher in neuro-oncology, with a primary focus on improving outcomes for patients with glioblastoma multiforme (GBM), the most aggressive form of brain cancer. His work centers on developing and evaluating salvage therapies for locally recurrent GBM, a notoriously difficult-to-treat condition where standard options are limited. Overholt’s most influential contribution is his prospective cohort study on fractionated stereotactic radiosurgery combined with concurrent temozolomide chemotherapy, which demonstrated a significant response rate and manageable toxicity for recurrent GBM patients. This landmark paper, with 56 citations, has helped shape modern salvage treatment protocols by providing evidence for a combined modality approach that extends survival while preserving quality of life. His research addresses a critical gap in GBM management, offering hope where few effective therapies exist. Overholt’s work is widely referenced in clinical guidelines and has influenced subsequent trials on radiosensitizers and dose fractionation. For students and researchers in neuro-oncology, his studies exemplify the rigorous translational research needed to tackle the most resistant brain tumors.
Research Focus
Key Achievements
Top Papers
- 1