Alexandra Lerchner
Papers
1
Total Citations
35
H-Index
1
About
Alexandra Lerchner is a pioneering researcher in the field of biocatalysis and enzyme engineering, with a focused expertise in developing sustainable, multi-step enzymatic processes for chemical synthesis. Her most notable contribution is the groundbreaking work on the coupled enzymatic conversion of isosorbide, a bio-based platform chemical, into valuable diamines. In her highly cited 2013 study, Lerchner engineered a matched pair of transaminases and dehydrogenases, meticulously optimizing substrate recognition, catalytic activity, and cofactor specificity. This innovative approach enabled a complex, one-pot biocatalytic cascade that transforms a bicyclic dialcohol into a diamine, a key building block for polymers and pharmaceuticals. With 35 citations, this work stands as a seminal reference in green chemistry and industrial biotechnology, demonstrating how tailored enzyme systems can replace traditional, harsh chemical routes. Lerchner’s research exemplifies the power of protein engineering to unlock new, environmentally friendly pathways for producing high-value compounds, making her a leading voice in the transition toward a bio-based economy.
Research Focus
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Top Papers
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