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About

Alexander Pryanichnikov is a leading figure in the advancement of gantry-less, upright proton therapy, a paradigm-shifting approach that promises to make this precise cancer treatment more accessible and cost-effective. His work centers on the clinical translation of fixed-beamline systems, where patients are treated in a seated or upright position rather than lying down. Dr. Pryanichnikov’s major contributions include the comprehensive commissioning of a novel synchrotron-based system, meticulously detailing its configuration and energy-layer delivery across a 4–38 cm range. He has also pioneered the clinical validation of this technology, leading the first prospective trial demonstrating the feasibility and safety of upright image-guided proton therapy for recurrent head and neck and brain malignancies. His research on patient positioning reproducibility, cited 10 times, is foundational for ensuring millimeter-level accuracy in this new treatment geometry. By proving that upright therapy is both practical and precise, Dr. Pryanichnikov is helping to eliminate the need for expensive rotating gantries, potentially expanding global access to proton therapy.