Adyary Fallarero

Papers

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About

Adyary Fallarero’s research focuses on the intersection of natural product chemistry and drug discovery, with key contributions in membrane permeability and high-throughput screening. Her most cited work investigates the bioavailability of coumarins—bioactive compounds abundant in human diet and herbal remedies—by evaluating their permeability across Caco-2 cell models. This foundational study, cited 26 times, provides critical insights into how coumarins traverse intestinal barriers, a first step toward understanding their oral bioavailability and therapeutic potential. A related paper (17 citations) further refines these permeability assessments, underscoring her systematic approach to pharmacokinetics. Fallarero also advanced pharmacological screening by developing a miniaturized radioligand competition assay for human α2-adrenoceptors, enabling high-throughput identification of novel modulators (8 citations). This work demonstrates her skill in bridging assay miniaturization with receptor pharmacology, offering tools for drug discovery. Her research is notable for its translational relevance—coumarins are widespread in nature and medicine—and her methodological innovations that enhance screening efficiency. With a career emphasizing rigorous permeability studies and receptor-targeted assays, Fallarero’s impact lies in providing foundational data for natural product-based therapeutics and scalable screening platforms, making her a valuable contributor to pharmaceutical sciences.