Locally Advanced Prostate Squamous Cell Carcinoma Diagnosed Using <scp>PET</scp>‐<scp>CT</scp> and Treated With Robot‐Assisted Radical Prostatectomy

Abstract

Introduction: Primary squamous cell carcinoma of the prostate accounts for < 1% of prostate cancers. Case Presentation: A 70-year-old man with no urinary symptoms and a normal prostate-specific antigen of 0.96 ng/mL was referred for abnormal prostate uptake on positron emission tomography-computed tomography. He was diagnosed with locally advanced squamous cell carcinoma of the prostate with lymph node metastasis. Robot-assisted radical prostatectomy and adjuvant chemoradiotherapy were administered. The patient remained in complete remission at 18 months postoperatively. Conclusion: Squamous cell carcinoma of the prostate should be suspected based on positron emission tomography-computed tomography prostate uptake. Robot-assisted radical prostatectomy may be feasible for locally advanced squamous cell carcinoma of the prostate; genetic profiling should be considered to identify targeted therapies.